There are some interesting threads going on in the Aptana Forums about using Aptana Studio with Adobe Flex and Flex Builder. The idea of using Ajax and Flex or Flash together is not new. Google Finance did a great job a few years ago blending the two to provide a very nice user experience with Flash-based interactive charts within an otherwise Ajax UI.
It seems that the Aptana community is uncovering increasing efficiencies in using Aptana Studio and Adobe's Flex Builder together. We've also known that many Adobe AIR users are building their Ajax apps for AIR using Aptana Studio, and have heard from others that using Aptana Jaxer to create JSON data services (written natively in JavaScript) consumable by Flash and Flex apps makes a lot of sense as well. Flash and Flex each have an "Ajax bridge" to expose JavaScript APIs for the embedded objects.
Anyways... It seems Adobe is now actively taking a deeper look at this trend in the hybridization of Ajax and Flash and Flex. I saw that they are offering $75 bucks for an hour phone call to discuss your experience with and thoughts on using these together.
Here's the link if you're interested: http://www.adobe.com/go/RIAintegration_study/. $75 bucks... That's almost the cost of a tank of gas in San Francisco.